- Overview
- Uses
- Benefits
- Side Effect
- How to use
- How It works
- What if you forget to take?
- Safety Advice
- FAQ
Author Details
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NepMeds
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Last Updated On: Aug 8, 2023
LEFRA-20MG
Rs. 0
Product Overview
Lefra is an immunosuppressive disease-modifying antirheumatic drug, used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase.
Using this medicine may cause some common side effects such as nausea, headache, dyspepsia, rash, diarrhea, increased liver enzymes, and respiratory tract infection. Consult with your doctor if any of these side effects do not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms
Uses
Lefra is primarily used for the treatment of rheumatoid arthritis, an autoimmune condition that causes joint inflammation, pain, and stiffness. The medication is specifically indicated for adults with active rheumatoid arthritis. It helps to alleviate the signs and symptoms of the disease and improve overall joint function and quality of life.
Some common symptoms of rheumatoid arthritis that Lefra can help address include:
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Joint pain: Lefra can help reduce joint pain, making movement and daily activities more comfortable.
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Joint swelling: Lefra can help reduce inflammation in the joints, leading to a decrease in joint swelling.
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Morning stiffness: Rheumatoid arthritis often causes morning stiffness, making it difficult to move the joints after waking up. Lefra can help alleviate morning stiffness, allowing for easier movement.
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Joint damage prevention: By reducing inflammation and suppressing the immune response, Lefra can help slow down the progression of joint damage associated with rheumatoid arthritis.
It is important to note that Lefra is used specifically for rheumatoid arthritis and is not indicated for other forms of arthritis or conditions. The use of Lefra should be under the supervision and guidance of a healthcare professional who will determine the appropriate dosage and duration of treatment based on individual needs and response.
Benefits
The use of Lefra (Leflunomide) for the treatment of rheumatoid arthritis offers several benefits. Here are some of the key benefits associated with Lefra:
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Reduction of Joint Inflammation: Lefra helps to reduce joint inflammation, which is a hallmark symptom of rheumatoid arthritis. By suppressing the immune response that causes inflammation, Lefra can alleviate pain, swelling, and stiffness in the affected joints.
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Improved Joint Function: With reduced inflammation, Lefra can help improve joint function and mobility. It allows individuals with rheumatoid arthritis to engage in daily activities more comfortably and with less pain.
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Disease Modification: Lefra is classified as a disease-modifying antirheumatic drug (DMARD). It has the potential to slow down the progression of rheumatoid arthritis and prevent further joint damage. By inhibiting the activity of immune cells involved in the inflammatory process, Lefra can help protect the joints from ongoing damage.
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Improved Quality of Life: Rheumatoid arthritis can significantly impact an individual's quality of life due to chronic pain, limited mobility, and functional impairment. Lefra's ability to reduce inflammation, relieve pain, and improve joint function can enhance overall well-being and quality of life for individuals with rheumatoid arthritis.
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Combination Therapy: Lefra can be used in combination with other medications for rheumatoid arthritis, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids. This combination approach may provide enhanced symptom relief and disease management.
It is important to note that the specific benefits and outcomes can vary among individuals, and the effectiveness of Lefra may depend on various factors, including the severity of the disease and individual response. It is crucial to consult with a healthcare professional who can assess your condition and guide you on the most appropriate treatment options for your specific needs.
Side Effect
Lefra (Leflunomide) may cause several side effects, although not everyone experiences them. Common side effects of Lefra include:
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Gastrointestinal Issues: These can include diarrhea, nausea, vomiting, stomach pain, and indigestion. Taking Lefra with food or dividing the daily dose can help reduce these symptoms.
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Hair Loss: Some individuals may experience hair thinning or hair loss while taking Lefra. This side effect is usually reversible once the medication is discontinued.
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Skin Reactions: Skin rash, itching, and dryness are possible side effects. Severe skin reactions, although rare, can occur. It is important to promptly inform your healthcare professional if you develop any skin-related issues.
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Elevated Liver Enzymes: Lefra can affect liver function and lead to increased liver enzymes in some individuals. Regular monitoring of liver function is typically recommended during treatment.
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Respiratory Issues: Lefra may cause respiratory symptoms such as coughing, difficulty breathing, or lung inflammation in rare cases. If you experience any respiratory issues, it is important to seek medical attention.
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Headache and Dizziness: Some individuals may experience headaches or dizziness while taking Lefra.
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Hypertension (High Blood Pressure): Lefra can sometimes lead to an increase in blood pressure. Regular monitoring of blood pressure is advisable during treatment.
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Blood Disorders: Rarely, Lefra may cause a decrease in the number of certain blood cells, such as white blood cells or platelets. Regular blood tests may be recommended to monitor for these potential effects.
It is important to discuss any potential side effects with your healthcare professional before starting Lefra. They can provide personalized information based on your medical history and assess the benefits versus risks of the medication. If you experience severe or persistent side effects while taking Lefra, it is important to seek medical advice promptly.
How to use
How It works
he main mechanism of action of Lefra is its ability to suppress the activity of the immune system. It works by inhibiting the proliferation of certain immune cells, particularly T cells, which are involved in the inflammatory process seen in rheumatoid arthritis. By reducing the activity of these cells, Lefra helps to alleviate joint inflammation and associated symptoms.
What if you forget to take?
If you forget to take a dose of Lefra (Leflunomide), it is generally recommended to take it as soon as you remember. However, if it is close to the time for your next scheduled dose, it is better to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.
It is important to maintain consistent use of Lefra for optimal effectiveness. If you frequently forget to take your medication or have difficulty remembering, consider using reminder tools such as setting alarms, using pill organizers, or incorporating it into your daily routine.
If you are uncertain about what to do when you miss a dose or have concerns about your dosing schedule, it is best to consult your healthcare professional for guidance. They can provide specific instructions based on your individual circumstances and advise you on the best course of action.
Safety Advice for LEFRA-20MG
Regular monitoring of blood tests, including liver function tests and complete blood counts, may be required while taking Lefra to ensure its safe use and detect any potential side effects
Pregnancy and Contraception: Lefra can cause harm to an unborn baby, so it is important to avoid pregnancy while taking Lefra and for a certain period after stopping the medication. Effective contraception methods should be used during treatment and for a recommended duration afterwards. Consult your healthcare professional for specific guidance.
Liver Function Monitoring: Lefra can affect liver function, so regular monitoring of liver enzymes is typically recommended during treatment. Inform your healthcare professional if you experience any symptoms of liver problems, such as jaundice (yellowing of the skin or eyes), dark urine, or persistent abdominal pain. Z
Alcohol Consumption: Alcohol can worsen certain side effects of Lefra, particularly liver-related side effects. It is advisable to limit or avoid alcohol consumption while taking Lefra.
Blood Tests: Regular blood tests may be required to monitor your blood cell counts and ensure that Lefra is not causing any adverse effects on your bone marrow.
Interactions with Other Medications: Inform your healthcare professional about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Some medications may interact with Lefra and affect its effectiveness or increase the risk of side effects. Vaccinations: Before starting Lefra, discuss with your healthcare professional the need for any vaccinations. Live vaccines should be avoided while on Lefra.
_Before starting Lefra, discuss with your healthcare professional the need for any vaccinations. Live vaccines should be avoided while on Lefra_
Frequently Asked Questions
Q: Can I drink alcohol while taking Lefra?
A: It is advisable to limit or avoid alcohol consumption while taking Lefra. Alcohol can increase the risk of liver-related side effects associated with the medication.
Q: Can I take Lefra during pregnancy or while breastfeeding?
A: Lefra should not be used during pregnancy as it may cause harm to the unborn baby. If you are planning to become pregnant or suspect you may be pregnant, discuss it with your healthcare professional. Lefra may also pass into breast milk, so it is important to consult your healthcare professional before breastfeeding while taking this medication.
Q: Can Lefra be stopped abruptly?
A: It is important not to stop taking Lefra abruptly without consulting your healthcare professional. They will provide guidance on the appropriate way to discontinue the medication, which may involve gradually reducing the dose over time.